So by now, I’ve fully grasped that, inside and out, except for the brain, a Nikke’s body is completely artificial but made to be as human like as possible while having typical robot stuff like cores and joints. Given they’ve mentioned cleaning out joints, would their skeletal structure have a 1:1 physical appearance of a human skeleton, just more robotic in nature?

The only thing i remember from canon scenes is Nikke's heads being cut off, and it doesn't seem to be a 1:1 skeletal structure. There also isn't a gyser of blood coming out either when Nikkes get beheaded, it's almost pretty clean with just some wires sticking out.

Could be blood censorship there, i dunno. The only blood i remember seeing is like some simple mouth blood which is more like "oil" or coolant running through their body.

Tetsamaru said in comment #2576122:

The only thing i remember from canon scenes is Nikke's heads being cut off, and it doesn't seem to be a 1:1 skeletal structure. There also isn't a gyser of blood coming out either when Nikkes get beheaded, it's almost pretty clean with just some wires sticking out.

Could be blood censorship there, i dunno. The only blood i remember seeing is like some simple mouth blood which is more like "oil" or coolant running through their body.

Iirc, in SR Rapi’s Bond 4, it’s mentioned that a Nikke’s “blood” is a sort of liquid catalyst to keep things functioning (which I believe would also be designed to keep the brain alive, due to being the only organic part). At first, said “blood” was green, but after many Nikkes underwent Mind Switches due to seeing themselves bleed green, it was changed to a blood red color.