Not really a genderswap, Spider-Girl is an official character.

The artist said on Twitter that he drew this after being inspired by Spider-Man 3, so not Spider-Girl in this case.

You say that but the look (costume, hair) is very much Spider-girl.

I don't think Peter is a redhead, so I'm convinced.

Spider-Girl, May 'Mayday' Parker, is the daughter of Peter Parker and Mary Jane Watson, who inherited her father's abilities and role. Earth-982, though, rather than the main universe of 616.

Popular enough to have her own fanbase, not popular enough for her books to not be canceled.

Still, looks like web-slinging is indeed a workout.