Space Ghost Coast to Coast is an American adult animated comedy late-night talk show created by Mike Lazzo for Cartoon Network and hosted by a re-imagined version of the cast of 1960s Hanna-Barbera cartoon Space Ghost, hosted by Space Ghost. It is the first TV show to be produced by Williams Street, the company to start up Adult Swim in the early 2000s.
To celebrate the series' 30th anniversary, Adult Swim streamed the series on YouTube in April 2024.