Alucard without his guns grind London to dust, absorbs a battalion of life of Waffen SS, devour the squadron of paladins of Iscariot Organization, and drinks the life of all citizen of London. Plus that one of Valentine vampires.
Vampires are overpowered without guns. They are like shackles for Onis.
I bet even Remi equipped herself with one. Desert Eagle or Beretta maybe?
Flan has been playing a lot of Borderlands as of late. She is following the good old slogan from Jakobs, "If it takes more than one shot. You weren't using a Jakobs." Though...I do think a Colt Python would follow under that.