NopeNopeNopeNope

Reminds me of that big-headed snake woman from Space Harrier 2.

Snakes... why did it have to be snakes?

[deleted]

Oversized head might be something about her ego getting to big
But yeah, we need the Pixiv commentary (heck, all of my posts in this pool is out of desperation to understand the stuff here)

Comment says :
御柱レイプ！邪神と化した神奈子　　やべえよ・・・やべえよ・・・　　　　　　 いつか来るであろう未来　―信仰を失って妖怪（あるいは邪神）に零落した自身の姿―　を恐れる神奈子の恐れの具現化。はじめは顔だけだったんですが、なんか物足りなかったので急遽、上半身を付け足しました。

It's also tagged as Siren, so it may be a reference to that game.

Really, I see people mention refrences to Space Harrier and Siren, but to me it reminds me of the giant Medusa Head boss from Castlevania: Lament of Innocence.