Yes. They're Stage 4 bosses, depending on which team you picked: Reimu for Marisa/Patchouli and Sakuya/Remilia, while Marisa for Reimu/Yukari and Youmu/Yuyuko.
Actually, one of the main reasons I played for Reimu/Yukari all the time was "Marisa is fucking hard, but Reimu is absolutely ridiculous." It's definitely more about picking your poison than selecting a team.