Kajita's running in the last panel of the left 4koma is either a reference to the Running Gangermeme or a reference to its sub-meme, Unstoppable Orga. Considering the source was posted about a month after the latter meme was posted, it could probably be either, but I chose to go with the Astroganger original.
fwishMaffiimo is here!So cute~~!!Take good care of it!Good night, Maffiimo ♡Let's play lots again tomorrow ♡Mischievious Kajita~~~!!Let's... get naughty...whumpOw!He he he he lololI can't stand this any more, I'm gonna wallop you with a hammer!He he he lol