I find this to be very amusing once I realize who are the characters they are each posing as.
From left to right: Natsuki as Josuke, who has an anger issue and daddy issues but otherwise a normal dude with the power to heal/repair anything except for himself and deaths; Yuri as Jotaro who also has an anger issue, is aloof, and got stabbed by many knives by the antagonist and eventually dies in a latter part of the story; Monika as Caesar Zeppeli, who is not a main character and comes from a family that has a tendency to die for more important character, and in fact did so at the end of the second act of that part of the story (by the way, this pose is very similar to Jonathan's pose, who is the first main character of the series); and Sayori as Jonathan Joestar who is one of the two Joestars to die, and still dies even as a different person after a cosmic retcon, in which he always dies with his head removed, and in the original timeline the antagonist then wears his body to replace his lost body.
That was just hilarious. And depressing. They can't escape their fate and issues even in a crossover fanart. Hm, Harsher in Hindsight/Clever pool?