Isn't true that Motoko isn't very compatible with males? Which is why she engages in lesbian cyber sex since the latter is painful?
I don't recall anything about sex being painful for her in anywhere. I believe it's more that she's pansexual. Possibly due to her barely identifying as human let alone a strict normative binary gender. Also, when you can interface directly with others' brains, it opens up a whole new realm of possibilities in sexual exploration, in that way, I think it might take less brain power to simultaneously experience multiple bodies' sensations when they match/are what she's more familiar with. In the original comic Bato interrupting her having sex ends up painful for him (immediately hacked to punch himself in the face) but that's all I can think of on the topic without writing an entire essay more fitting of an undergratuate gender studies course.